c(RGDfC)-PEG-PCL靶向纳米载体的合成及其条件优化Synthesis and Optimization of C(RGDfC)-PEG-PCL Targeted Nanocarriers
张旭;葛飞;朱龙宝;李婉珍;宋平;陶玉贵;
摘要(Abstract)：
利用迈克尔加成法制备了c(RGDfC)-PEG-PCL靶向纳米载体,用质谱、核磁等对其进行表征,探讨反应时间、pH值、温度、催化剂以及溶剂对合成率的影响。当反应时间为24 h、pH值在7.5～8.0、温度为25℃、碱性催化剂为DIEA、反应溶剂为DMF时,靶向环肽c(RGDfC)(50.0 mg)和马来酰亚氨基-聚乙二醇-聚己内酯(10.0 mg, Mal-PEG_(113)-PCL_(55))反应生成c(RGDfC)-PEG_(113)-PCL_(55),产率为72.6%。
关键词(KeyWords)： 靶向;纳米载体;合成效率;合成条件
基金项目(Foundation): 国家自然科学基金资助项目(31671797);; 安徽省高等学校省级自然科学研究重点基金资助项目(KJ2017A123、KJ2018A0117);; 安徽省高等学校省级自然科学研究基金资助项目(KZ00217058);; 国家级大学生创新创业训练计划基金资助项目(201710363084、201710363177)
作者(Author): 张旭;葛飞;朱龙宝;李婉珍;宋平;陶玉贵;
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参考文献(References)：
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